SAP Integration Suite is an integration platform as a service that runs on SAP Business Technology Platform (BTP). It bundles Cloud Integration, which connects cloud and on-premises systems through integration flows, API Management for creating, securing and monitoring APIs, Event Mesh for event-driven exchange between SAP and non-SAP applications, and tooling for B2B integration. It is aimed at organisations that connect SAP landscapes with other applications and is delivered as a cloud service whose capabilities you enable in a subaccount via the SAP BTP cockpit.
SAP SE is a European company headquartered in Walldorf, Germany. The service is proprietary. For organisations that want to keep processing local, SAP offers a hybrid option, the Edge Integration Cell, part of its private landscape offering. It runs on a Kubernetes environment, stores and processes data locally and leaves operational control with the customer. Region availability of the cloud service differs by subscription, so check SAP's documentation for the regions that apply to you.